About
Pawel Namsolleck, Ph.D.
Drug development process became extremely complex in the recent years and usually is managed by a team of experts and scientists. With my expertise in pharmacology gained at Charité Berlin and in drug development as a Head of Nonclinical Development at Lanthio Pharma, I would like to support your drug development programs with tailored high-quality solutions in preclinical activities and data analytics to meet your needs.
Download My Cv
| Titel | Authors | References |
|---|---|---|
|
2023 Galanin 2 Receptor: A Novel Target for a Subset of Pancreatic Ductal Adenocarcinoma |
Namsolleck P, Kofler B, Moll GN |
Int. J. Mol. Sci. 2023, 24(12) |
|
LP2, a stable lanthipeptide derived from cAng-(1-7), exerts myeloprotective action in mice |
Namsolleck P, Rodgers KE, Franklin R, Moll GN |
Eur J Haematol. 2023 May;110(5):534-539 |
|
LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice |
Namsolleck P, de Vries L, Moll GN |
Peptides. 2023 Feb;160:170920 |
|
2021
LP2, the first lanthipeptide GPCR agonist in a human pharmacokinetics and safety study |
Namsolleck P, Richardson A, Moll GN, Mescheder A |
Peptides. 2021 Feb;136:170468 |
|
2020
Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors |
Moll GN, Kuipers A, Rink R, Bosma T, de Vries L, Namsolleck P |
Biochem Soc Trans. 2020 Oct30;48(5):2195-2203 |
|
Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19? |
Namsolleck P, Moll GN |
Mol Med.2020 Aug 17;26(1):80 |
|
2018
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat |
Lange C, Sommerfeld M, Namsolleck P, Kintscher U, Unger T, Kaschina E |
Hypertension.2018 Sep;72(3):e20-e29 |
|
Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice |
Foulquier S, Namsolleck P, Van Hagen BT, Milanova I, Post MJ, Blankesteijn M, Rutten B, Prickaerts J, Van Oostenbrugge RJ, Unger T |
Hypertens Res.2018 Oct;41(10):817-827 |
|
2017
AT2 receptors in cardiovascular and renal diseases |
Kaschina E, Namsolleck P, Unger T |
Pharmacol Res. 2017 Nov;125(Pt A):39-47 |
|
Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS |
Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM |
Hypertension. 2017 Jun;69(6):1128-1135 |
|
2016
Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice |
Schwengel K, Namsolleck P, Lucht K, Clausen BH, Lambertsen KL, Valero-Esquitino V, Thöne-Reineke C, Müller S, Widdop RE, Denton KM, Horiuchi M, Iwai M, Boato F, Dahlöf B, Hallberg A, Unger T, Steckelings UM |
J Mol Med (Berl). 2016 Aug;94(8):957-66 |
|
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders |
Paulis L, Foulquier S, Namsolleck P, Recarti C, Steckelings UM, Unger T |
Drugs. 2016 Jan;76(1):1-12 |
|
2015
Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice |
Valero-Esquitino V, Lucht K, Namsolleck P, Monnet-Tschudi F, Stubbe T, Lucht F, Liu M, Ebner F, Brandt C, Danyel LA, Villela DC, Paulis L, Thoene-Reineke C, Dahlöf B, Hallberg A, Unger T, Sumners C, Steckelings UM |
Clin Sci (Lond). 2015 Jan;128(2):95-109 |
|
Activation of intracellular angiotensin AT₂ receptors induces rapid cell death in human uterine leiomyosarcoma cells |
Zhao Y, Lützen U, Fritsch J, Zuhayra M, Schütze S, Steckelings UM, Recanti C, Namsolleck P, Unger T, Culman J |
Clin Sci (Lond). 2015 May;128(9):567-78 |
|
2014
Role of cardiovascular risk factors in the etiology of dementia |
Namsolleck P, Schmerler P, Unger T |
MMW Fortschr Med. 2014 Dec 15;156(21-22):83-4 |
|
Aldosterone synthase inhibitors in cardiovascular and renal diseases |
Namsolleck P, Unger T |
Nephrol Dial Transplant. 2014 Feb;29 Suppl 1:i62-i68 |
|
AT(2) receptor and tissue injury: therapeutic implications |
Namsolleck P, Recarti C, Foulquier S, Steckelings UM, Unger T |
Curr Hypertens Rep. 2014 Feb;16(2):416 |
|
2013
AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression |
Namsolleck P, Boato F, Schwengel K, Paulis L, Thöne-Reineke C, Lucht K, Seidel K, Hallberg A, Dahlöf B, Unger T, Steckelings UM |
Neurobiology of Disease. 2013; 51:177-191 |
|
2012
AT2 receptor agonists: hypertension and beyond |
Steckelings UM, Paulis L, Namsolleck P, Unger T |
Curr Opin Nephrol Hypertens. 2012 Mar;21(2):142-6 |
|
Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis |
Winkler R, Benz V, Clemenz M, Bloch M, Foryst-Ludwig A, Wardat S, Witte N, Trappiel M, Namsolleck P, Mai K, Spranger J, Matthias G, Roloff T, Truee O, Kappert K, Schupp M, Matthias P, Kintscher U |
Diabetes. 2012 Feb;61(2):513-23 |
|
2011
Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models |
Thoene-Reineke C, Rumschüssel K, Schmerbach K, Krikov M, Wengenmayer C, Godes M, Mueller S, Villringer A, Steckelings U, Namsolleck P, Unger T |
PLoS One. 2011;6(8):e23646 |
|
Non-peptide AT2-receptor agonists |
Steckelings UM, Larhed M, Hallberg A, Widdop RE, Jones ES, Wallinder C, Namsolleck P, Dahlöf B, Unger T |
Curr Opin Pharmacol. 2011 Apr;11(2):187-92 |
|
2010
The past, present and future of angiotensin II type 2 receptor stimulation |
Steckelings UM, Rompe F, Kaschina E, Namsolleck P, Grzesiak A, Funke-Kaiser H, Bader M, Unger T |
J Renin Angiotensin Aldosterone Syst. 2010 Mar;11(1):67-73 |
|
2008
AT2-receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin-system in myocardial infarction? |
Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, Sommerfeld M, Kemnitz U, Curato C, Namsolleck P, Tschoepe C, Hallberg A, Alterman M, Dahlöf B, Kintscher U, Unger T, Steckelings U |
Circulation. 2008 Dec 9;118(24):2523-32 |
|
The beta-lactam antibiotic, ceftriaxon, dramatically reduces acute stroke mortality by stimulating glutamate transporter activity |
Thöne-Reineke C, Neumann C, Namsolleck P, Schmerbach K, Krikov M, Schefe J, Lucht K, Hörtnagl H, Godes M, Müller S, Rumschüssel K, Funke Kaiser H, Villringer A, Steckelings UM, Unger T |
J. Hypertens. 2008 Dec;26(12):2426-35 |
|
2007
Centrifugation of bacterial cells on slide surface improves the spatial distribution, cell recovery and reduces the time of enumeration for fluorescence in situ hybridization |
Namsolleck P, Mohan R, Koebnick C, Blaut M |
J Microsc. 2007 Jul;227(Pt 1):8-14 |
|
2006
Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease |
Ott S, Mokhtari NE, Musfeldt M, Hellmig S, Smalla K, Namsolleck P, Blaut M, Hampe J, Sahly H, Reinecke A, Haake N, Günther R, Krüger D, Lins M, Herrmann G, Fölsch UR, Simon R, Schreiber S |
Circulation 2006 Feb;113(7):929-37 |
|
Clostridium asparagiforme sp. nov., isolated from a human faecal sample |
Mohan R, Namsolleck P, Lawson PA, Osterhoff M, Collins MD, Alpert C, Blaut M |
Syst. Appl Microbiol 2006 Jun;29(4):292-9 |
|
2005
Impact of cereal fibre on glucose-regulating factors |
Weickert MO, Moehlig M, Koebnick C, Osterhoff M, Ristow M, Namsolleck P, Holst JJ, Rudovich N, Rochlitz H, Spranger J, Pfeiffer AFH |
Diabetologia 2005 Nov;48(11):2343-53 |
|
Colonic microbiota signatures across five northern European countries |
Lay C, Rigottier-Gois L, Holmstrøm K, Rajilić M, E. Vaughan E, de Vos WM, Collins MD, Thiel R, Namsolleck P, Blaut M and Doré J |
Appl Environ Microbiol 2005 Jul;71(7):4153-5 |
|
2004
Solubilizing poorly soluble antimycotic agents by emulsification via a solvent-free process |
Akkar A, Namsolleck P, Blaut M, Muller RH |
AAPS PharmSciTech 2004 Apr;5(1):E24 |
|
Molecular methods for the analysis of gut microbiota |
Namsolleck P, Thiel R, Lawson P, Holmstrøm K, Rajilic M, Vaughan E, Rigottier-Gois L, Collins MD, de Vos WM, Blaut M |
Microbial Ecology in Health and Disease 2004 Sep;16(2-3):71-85 |
|
1998
Anthropogenic Organic Substances, Origin, Distribution and Impact on the Water Ecosystem |
Niemirycz E, Bierawska B, Błazejewski J, Cedynska A, Dojlido J, Heybowicz E, Judycka U, Kaczmarczyk A, Lammek B, Namsolleck P, Taylor R, Sosnowska M, Szafranek J, Szczerski, R |
The International Odra Project. Annual Report 1998, Hamburg University |